Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data
نویسندگان
چکیده
منابع مشابه
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data
BACKGROUND The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, time-consuming and require large numbers of animals. For early toxicity screening, in silico models can b...
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ژورنال
عنوان ژورنال: Chemistry Central Journal
سال: 2015
ISSN: 1752-153X
DOI: 10.1186/s13065-015-0139-7